Micro-RNA Expression in the Urinary Sediment of Patients with Chronic Kidney Diseases
نویسندگان
چکیده
منابع مشابه
Micro-RNA Expression in the Urinary Sediment of Patients with Chronic Kidney Diseases
BACKGROUND Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. METHODS We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patients were followed for 16.2 ± 15.5 months. RESULTS Patients with diabetic gl...
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BACKGROUND The degree of renal scarring in kidney biopsy is an important prognostic factor in patients with chronic kidney diseases. We hypothesize that gene expression in the urinary sediment reflects the degree of renal damage. METHODS We studied 29 patients with chronic kidney disease who underwent kidney biopsy (12 immunoglobulin-A nephropathy and 17 glomerulosclerosis) and 10 healthy con...
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Evaluation of gene expression in urinary sediment has been considered as a promising non-invasive approach for biomarker identification of kidney diseases. Nonetheless, there are several challenges in extraction of RNA from this valuable source of biomarkers, mostly because of the factors that have influence on quality of isolated RNA such as low cellular content. Accordingly, we compared the q...
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ژورنال
عنوان ژورنال: Disease Markers
سال: 2012
ISSN: 0278-0240,1875-8630
DOI: 10.1155/2012/842764